Research & Publications – Oral Health

Manpreet, B., MacRobert, A., Meghji, S., Henderson, B., and Wilson, M., 1998.  A Study of the Uptake of Toluidine Blue O by Porphyromonas gingivalis and the Mechanism of Lethal Photosensitization, Photochemistry and Photobiology, v. 68, p. 370-376.

Wilson, M., Burns, T., Pratten, J., and Pearson, G.J., 1995., Bacteria in supragingival plaque samples can be killed by a low-power laser light in the presence of a photosensitizer.  Journal of Applied Bacteriology, v. 78, p. 569-574.

Chan, Y., and Lai, C., 2003.  Bactericidal effects of different laser wavelengths on periodontopathic germs in photodynamic therapy, Lasers in Medicine and Science, v. 18, p. 51-55.

Hayek, R.R. A., Araujo, N.S. Gioso, M.A. , Ferreira J., Baptista-Sobrinho C.A., Yamada Jr. A. M., Riberiro, M.S.2005.Comparative Study Between the Effects of Photodynamic Therapy and Conventional Therapy on Microbial Reduction in Ligature – Induced Peri-Implantitis in Dogs

Qin, Y.L., Luan, X.L., Bi, L.J., Sheng Y.Q, C. N. Zhou, C. N., Zhang, Z.G. 2008. Comparison of TBO mediated PDT and conventional scaling treatment for periodontitis in rats. J. Periodont. Res, v 43, p.162-167.

Manpreet, B., MacRobert, A., Meghji, S., Henderson, B., and Wilson, M., 1997.  Effect of dosimetric and physiological factors on the lethal photosensitization of Porphyromonas gingivalis in vitro, Photochemistry and Photobiology, v. 65, p. 1026-1031.

Sigusch, B., Pfitzner, A. Albrecht, V., Glockmann, E., 2005. Efficacy of Photodynamic Therapy on Inflammatory Signs and Two Selected Periodontopathogenic Species in a Beagle Dog Model, Journal of Perodontol, Vol. 76, No. 7, p. 1100-1105.

Bhatti, M., MacRobert, A., Henderson, B., and Wilson, M., 1998., Exposure of Porphyromonas gingivalis to red light in the presence of the light-activated antimicrobial agent Toluidine Blue O decreases membrane fluidity.  Current Microbiology, v. 45, p. 118-122.

Luan, X., Qin, Y., Bi, L., Hu, C., Zhang, Z., Lin, J., Zhou, C., 2007, Histological evaluation of the safety of toluidine blue-mediated photosensitization to periodontal tissues in mice. Lasers in Medical Science.

Bonito, A.J., Lux, L., and Lohr, K.N., 1997.  Impact of local adjuncts to scaling and root planing in periodontal disease therapy: A systematic review, Journal of Periodontology, v. 76, p. 1227-1236.

Wilson M, Dobson J, Harvey W. Sensitisation of oral bacteria to killing by low-power laser radiation. Current Microbiol 1992; 25: 77-81

Wilson M, Dobson J, Sarkar S Sensitisation of periodontopathogenic bacteria to killing by light from a low-power laser.. Oral Microbiol Immunol 1993; 8: 182-187

Sarkar S, Wilson M.Lethal photosensitisation of bacteria in subgingival plaque samples from patients with chronic periodontitis. J Periodont Res 1993; 28: 204-210

Wilson M. Photolysis of oral bacteria and its potential use in the treatment of caries and periodontal disease: a review. J Appl Bact 1993; 75: 299-306

Wilson M, Dobson J Lethal photosensitization of oral anaerobic bacteria.  Wilson M, Dobson J. Clin Infect Dis 1993; 16: 414-415

Wilson M, Mia N Sensitisation of Candida albicans to low-power laser light.. J Oral Pathol Med 1993; 22: 354-357

Burns T, Wilson M, Pearson G.Sensitisation of cariogenic bacteria to killing by light from a helium/neon laser. J Med Microbiol 1993; 38: 401-405

Wilson M Bactericidal effect of laser light and its potential use in the treatment of  plaque-related diseases.. Int Dent J 1994; 44: 181-189

Burns T, Wilson M, Pearson G Killing of cariogenic bacteria by light from a gallium arsenide diode laser. J Dentistry 1994; 22: 273-278

Wilson M Lethal photosensitization of oral anaerobic bacteria. Infect Dis Digest 1994: 1: 27-28

Wilson M, Mia N Effect of environmental factors on the lethal photosensitization of Candida     albicans in vitro. Las Med Sci 1994; 9: 105-109

Wilson M, Burns T, Pratten J, Pearson GJ. Bacteria in supragingival plaque samples can be killed by low-power laser light in the presence of a photosensitiser. J Appl Bacteriol  1995; 78: 569-574

Burns T, Wilson M, Pearson G. Effect of dentine and collagen on the lethal photosensitisation of Streptococcus mutans.Caries Res  1995; 29: 192-197

Burns T, Wilson M, Pearson GJ Mechanism of killing of Streptococcus mutans by light-activated drugs. J Proc SPIE 1995; 2625: 288-297

Wilson M, Burns T, Pratten J. Killing of Streptococcus sanguis in biofilms using a light-activated antimicrobial agent. J Antimicrob Chemother 1996; 37: 377-381

Soukos NS, Wilson M, Burns T, Speight PM.The photodynamic effects of toluidine blue on human oral keratinocytes and fibroblasts and Streptococcus sanguis evaluated in vitro. Las Surg Med 1996; 18: 253-259

Bhatti M, MacRobert AJ, Meghji S, Henderson B, Wilson M.Effect of dosimetric and physiological factors on the lethal photosensitisation of Porphyromonas gingivalis in vitro. Photochem Photobiol 1997; 65: 1026-1031

Wilson M Lethal photosensitisation of biofilm-grown bacteria. J Proc SPIE 1997; 3191: 68‑78

Bhatti M, MacRobert AJ, Meghji S, Henderson B, Wilson M A study of the uptake of toluidine blue O by Porphyromonas gingivalis and the mechanism of lethal photosensitisation Photochem Photobiol 1998; 68: 370-376

Jackson Z, Meghji S, MacRobert A, Henderson B, Wilson M. Killing of the yeast and hyphal forms of Candida albicans using a light-activated  antimicrobial agent Las Med Sci 1999; 14: 150-157

Eds: Busscher HJ, Evans LV Control of oral biofilms by light-activated antimicrobial agents Wilson M In: Oral Biofilms and Plaque Control.. Harwood Academic Publishers, 1999, 323-340.

Packer S, Wilson M  Inactivation of proteolytic enzymes from Porphyromonas gingivalis using light-activated agents. Las Med Sci 2000; 15: 24-30

Bhatti M, MacRobert A, Henderson B, Shepherd P, Cridland J, Wilson M. Antibody-targeted lethal photosensitisation of Porphyromonas gingivalis. Antimicrob Agents Chemother  2000; 44: 2615-2618.

Kömerik N, Wilson M, Poole S. The effect of photodynamic action on two virulence factors of Gram-negative bacteria. Photochem Photobiol 2000; 72: 676-680

Wainwright M, Wilson M. Showing bugs the red light. Chemistry and Industry  2001; 4: 112-115

Bhatti M, Nair SP, MacRobert AJ, Henderson B, Shepherd P, Cridland J, Wilson M. Identification of photolabile outer membrane proteins of Porphyromonas gingivalis.Current Microbiol 2001: 43; 96-99

Kömerik N, Curnow A, MacRobertAJ, Hopper C,  Speight PM, Wilson M Fluorescence biodistribution and photosensitising activity of toluidine blue O on rabuccal mucosa. Las Med Sci  2002; 17: 86-92

Wainwright M, Wilson M. Showing bugs the red light. Chemistry and Industry  2001; 4: 112-115

Bhatti M, Nair SP, MacRobert AJ, Henderson B, Shepherd P, Cridland J, Wilson M. Identification of photolabile outer membrane proteins of Porphyromonas gingivalis. Current Microbiol 2001: 43; 96-99

Kömerik N, Curnow A, MacRobertAJ, Hopper C,  Speight PM, Wilson M Fluorescence biodistribution and photosensitising activity of toluidine blue O on rabuccal mucosa. Las Med Sci  2002; 17: 86-92

Kömerik N,  Wilson M Factors influencing the susceptibility of Gram-negative bacteria to toluidine blue O- mediated lethal photosensitisation. J Appl Microbiol  2002; 92: 618-623

Bhatti M, MacRobert AJ, Henderson B, Wilson M.  Exposure of Porphyromonas gingivalis to red light in the presence of the light-activated antimicrobial agent toluidine blue decreases membrane fluidity.            Current Microbiol  2002: 45: 118-122

Nakanishi H, MacRobert AJ, Henderson B, Speight P, Wilson M  In vivo killing of Porphyromonas gingivalis by toluidine blue-mediated photosensitization in an animal model  K Antimicrob Ag Chemother  2003; 47: 932-40.

O’Neill J, Wilson M, Wainwright M.Comparative antistreptococcal activity of photobactericidal agents. J Chemother. 2003; 15: 329-34.

Williams JA, Pearson GJ, Colles MJ, Wilson M.The effect of variable energy input from a novel light source on the photoactivated bactericidal action of toluidine blue Caries Res. 2003; 37: 190-3.

R, Loebel N, Hammond D, Wilson M. Treatment of periodontal disease by photodisinfection compared to scaling and root planing. J Clin Dent 2007; 18: 34-38

I, O’Neill J, Hope C. Susceptibility of microcosm subgingival dental plaques to lethal photosensitisation Allan  Biofilms  2007 Published online 17 Dec

Bourre L, Giuntini F, Eggleston I, Wilson M, MacRobert  5-aminolaevulinic acid peptide prodrugs enhance photosensitisation for photodynamic therapy AJMol Can Ther 2008; 7: 1720-9.

Giuntini F, Bourre L, MacRobert AJ, Wilson M, Eggleston IM  Improved peptide prodrugs of 5-ALA for PDT: rationalization of cellular      accumulation and protoporphyrin IX production by direct determination of cellular      prodrug uptake and prodrug metabolization.       J. Medicinal Chem 2009; 52; 4026-4037

Bourré L, Giuntini F, Eggleston IM, Mosse CA, Macrobert AJ, Wilson M. Effective photoinactivation of Gram-positive and Gram-negative bacterial strains       using an HIV-1 Tat peptide-porphyrin conjugate. Photochem Photobiol Sci. 2010; 9: 1613-1620

Gil-Tomás, J. Dekker L, Narband N, Parkin IP, Nair SP, Street C, Wilson M Lethal photosensitisation of bacteria using a tin chlorin e6–glutathione–gold nanoparticle conjugate J. Mater. Chem, 2011; 21; 4189-4196

Wilson M. Lethal photosensitisation of oral bacteria and its potential application in the photodynamic therapy of oral infections. Photochem Photobiol Sci  2004: 3: 412-8.

O’Neil JF, Wilson M, Wainwright M.Comparative antistreptococcal activity of photobactericidal agents. J Chemother. 2003; 15: 329-34.

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